A review of the pathophysiology of recurrent implantation failure
| Autor: | Jason M. Franasiak, Eric J. Forman, Emre Seli, Sam Schoenmakers, Joop S.E. Laven, Natalia C. Llarena, Diana Alecsandru, Cheri K. Margolis, Jeffrey M. Goldberg, Laura C. Gemmell |
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| Rok vydání: | 2021 |
| Předmět: |
Pregnancy Rate
Endometriosis Fertilization in Vitro Endometrium Bioinformatics Human reproduction Pregnancy Recurrence medicine Humans Recurrent implantation failure aneuploidy endometrial receptivity microbiome Endocrine system Embryo Implantation Treatment Failure Blastocyst Microbiome business.industry Obstetrics and Gynecology Embryo Embryo Transfer Embryonic stem cell Pathophysiology medicine.anatomical_structure Reproductive Medicine Female business |
| Zdroj: | FERTILITY AND STERILITY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 0015-0282 |
| Popis: | Implantation is a critical step in human reproduction. The success of this step is dependent on a competent blastocyst, receptive endometrium, and successful cross talk between the embryonic and maternal interfaces. Recurrent implantation failure is the lack of implantation after the transfer of several embryo transfers. As the success of in vitro fertilization has increased and failures have become more unacceptable for patients and providers, the literature on recurrent implantation failure has increased. While this clinical phenomenon is often encountered, there is not a universally agreed-on definition—something addressed in an earlier portion of this Views and Reviews. Implantation failure can result from several different factors. In this review, we discuss factors including the maternal immune system, genetics of the embryo and parents, anatomic factors, hematologic factors, reproductive tract microbiome, and endocrine milieu, which factors into embryo and endometrial synchrony. These potential causes are at various stages of research and not all have clear implications or immediately apparent treatment. |
| Databáze: | OpenAIRE |
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