Bisphosphonates as Supplement to Dental Treatment: A Network Meta-Analysis
| Autor: | Vasileios F. Zymperdikas, Eleftherios G. Kaklamanos, Maria P. Yavropoulou, Moschos A. Papadopoulos |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Periodontal tissue medicine.medical_specialty Diphosphonates business.industry medicine.medical_treatment Network Meta-Analysis 030206 dentistry Bisphosphonate Zoledronic Acid Bone remodeling 03 medical and health sciences 0302 clinical medicine Meta-analysis Internal medicine Drug delivery Humans Medicine In patient 030212 general & internal medicine Bone biology Bone Diseases business General Dentistry Periodontal Diseases |
| Zdroj: | Journal of Dental Research. 100:341-351 |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/0022034520972945 |
| Popis: | The objective of this study was to assess clinical measurements related to the effectiveness of bisphosphonate (BP) administration as a supplement to conventional dental treatment in patients free of bone-related diseases using a network meta-analysis. Only randomized controlled trials (RCTs) were included that provided dental clinical measurements on human patients treated with BPs with or without similar untreated controls or treated with placebo. Information sources included a systematic search of 17 electronic databases up to August 2020, complemented by manual searches. Risk of bias assessment was performed with the revised Cochrane risk of bias tool for randomized trials (RoB 2.0). Extracted measurements were pooled according to time of evaluation. The random-effects model by DerSimonian and Laird was used to calculate mean differences (MDs) and the respective 95% confidence intervals (CIs). Seven RCTs were included in the network meta-analysis, assessing 391 subjects reporting on periodontal treatment effects after 2 to 12 mo of BP administration. BP treatment was associated with significant improvement of most clinical measurements, compared with BP-naive controls. According to the network ranking, alendronate was more efficient in improvement of probing depth and clinical attachment gain when compared to zoledronate or alendronate/risedronate. Similarly, the local application of alendronate as a gel was more effective than the oral administration. A long-term analysis of the pharmaceutical effects was not possible due to insufficient data. The current review, performed according to existing guidelines, included only RCTs and, through appropriate statistical analyses, provided precise estimates for most assessed outcomes. However, no adverse effects or long-term treatment results were analyzed due to inadequate pertinent data. BP administration seems to be beneficial in the short term for the treatment of periodontal diseases, mainly through controlling periodontal inflammation. |
| Databáze: | OpenAIRE |
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