Emerging relationship between RNA helicases and autophagy
| Autor: | Zheng-Gang Yang, Yan-Lin Zhou, Miao-Miao Zhao, Rusha Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Carcinogenesis Cell Survival RNA Splicing Cellular homeostasis Review Biology Antiviral Agents General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Neoplasms Autophagy Animals Homeostasis Humans Receptors Immunologic General Pharmacology Toxicology and Pharmaceutics General Veterinary Translation (biology) General Medicine RNA Helicase A Cell biology 030104 developmental biology Gene Expression Regulation Immune System 030220 oncology & carcinogenesis RNA splicing Disease Progression DEAD Box Protein 58 Beclin-1 RNA Helicases Function (biology) Intracellular |
| Zdroj: | J Zhejiang Univ Sci B |
| ISSN: | 1862-1783 1673-1581 |
| DOI: | 10.1631/jzus.b2000245 |
| Popis: | RNA helicases, the largest family of proteins that participate in RNA metabolism, stabilize the intracellular environment through various processes, such as translation and pre-RNA splicing. These proteins are also involved in some diseases, such as cancers and viral diseases. Autophagy, a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival, is associated with human diseases. Interestingly, similar to autophagy, RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases. According to recent studies, RNA helicases are closely related to autophagy, participate in regulating autophagy, or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progression of diseases. Here, we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases. |
| Databáze: | OpenAIRE |
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