Effect of Surfactant Mixtures on Skin Structure and Barrier Properties
| Autor: | Brittney Hellner, Monica A. James-Smith, Nancy Annunziato, Samir Mitragotri |
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| Rok vydání: | 2010 |
| Předmět: |
Swine
Biomedical Engineering In Vitro Techniques Article Permeability Surface-Active Agents chemistry.chemical_compound Pulmonary surfactant Bromide Surfactant Spectroscopy Fourier Transform Infrared Mixture Stratum corneum medicine Animals Sodium dodecyl sulfate Skin Transdermal Chromatography integumentary system Chemistry Electric Conductivity Sodium Dodecyl Sulfate Penetration (firestop) Quaternary Ammonium Compounds Synergy Monomer medicine.anatomical_structure Skin structure Mechanism |
| Zdroj: | Annals of Biomedical Engineering |
| ISSN: | 1573-9686 0090-6964 |
| DOI: | 10.1007/s10439-010-0190-4 |
| Popis: | We investigated the effect of two commonly studied surfactants, sodium dodecyl sulfate (SDS) and dodecyl trimethylammonium bromide (C(12)TAB), on skin barrier properties. Using skin conductivity, FT-IR of stratum corneum samples, and penetration of radiolabelled SDS, we determined that addition of C(12)TAB lowers the ability of SDS to perturb skin's barrier properties. Ultrafiltration experiments revealed that addition of C(12)TAB serves to decrease the concentration of monomers and sub-micellar aggregates. None of the measured skin properties including enhancement of skin conductivity, perturbation of lipid structure and skin concentration of SDS correlated with the total SDS concentration in the donor compartment (i.e., the total SDS concentration). However, all these parameters correlated well against the concentration of monomers and sub-micellar aggregates. These findings provide the evidence of the importance of monomer and sub-micellar components in altering skin barrier properties. |
| Databáze: | OpenAIRE |
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