Drosophila melanogaster contains both X-linked and autosomal homologues of the gene encoding calcineurin B
| Autor: | Phillips Am, Warren Wd, Howells Aj |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
X Chromosome
Genetic Linkage Protein subunit Molecular Sequence Data Restriction Mapping Genes Insect Transcription (biology) Genetics Coding region Animals Humans Amino Acid Sequence Gene X chromosome Polytene chromosome biology Base Sequence Sequence Homology Amino Acid Calcineurin Calcium-Binding Proteins Intron General Medicine DNA biology.organism_classification Blotting Northern Molecular biology Drosophila melanogaster |
| Zdroj: | Gene. 177(1-2) |
| ISSN: | 0378-1119 |
| Popis: | A transcription unit was identified in the 43E polytene band region of the second chromosome of Drosophila melanogaster (Dm) whose putative translation product has 85% amino acid (aa) identity with the B subunit of the calcineurin protein (CnB) from humans. Unlike the previously described intronless Dm CnB gene homologue, which is located within the 4F band region of the X chromosome, the coding region of this second CnB is found to be interrupted by three introns. Conceptual translation of both Dm CnB genes predict proteins of identical size that are 98% identical in aa sequence. Northern blot analyses indicate that Dm pupae and adults express two different CnB-encoding transcripts that are differentially regulated. |
| Databáze: | OpenAIRE |
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