Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: Report of a very rare case
| Autor: | Yusuke Shiraishi, Seiichi Hirota, Mayumi Nakai, Masataka Zozumi, Hiroyuki Hao, Ikuo Matsuda, Yoshitane Tsukamoto, Michio Nojima, Shingo Yamamoto |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Oncogene Proteins Fusion Molecular Sequence Data Chromosomal translocation Round Cell Liposarcoma Chimeric gene Biology Liposarcoma Spermatic cord Pathology and Forensic Medicine Fusion gene medicine Humans Base Sequence Reverse Transcriptase Polymerase Chain Reaction Mesenchymal stem cell Cell Biology Anatomy Middle Aged medicine.disease Liposarcoma Myxoid medicine.anatomical_structure Genital Neoplasms Male Scrotum Genital neoplasm RNA-Binding Protein FUS Transcription Factor CHOP |
| Zdroj: | Pathology - Research and Practice. 209:124-127 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2012.10.015 |
| Popis: | Myxoid/round cell liposarcomas are rare mesenchymal neoplasms. They preferentially occur in the lower extremity, and most of them have type 1 or type 2 DDIT3-FUS fusion gene. We report here a very rare case of myxoid/round cell liposarcoma of the paratesticular region with type 3 DDIT3-FUS fusion gene. A 46-year-old Japanese man noticed a gradually enlarged intrascrotal mass without pain. Surgical resection of 3.4 cm × 2.1 cm oval mass was carried out, and it was located in the right paratesticular region apart from the spermatic cord and epididymis. Histological examination of the tumor revealed ovoid cell proliferation with anastomosing vascular network and scattered lipoblasts. Genetic analysis elucidated that the tumor had a chromosomal translocation, type 3 DDIT3-FUS chimeric gene. The tumor was definitely diagnosed as myxoid/round cell liposarcoma of the paratesticular region. |
| Databáze: | OpenAIRE |
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