[Risk factors for atherosclerosis in children and adolescents with family history of premature coronary artery disease]
| Autor: | Jayme Diament, Ary Lopes Cardoso, Ceres Concilio Romaldini, Neusa Assumpta Forti, Hugo Issler |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Arteriosclerosis Hyperlipidemias Coronary Artery Disease Coronary artery disease Reference Values Risk Factors Internal medicine medicine Humans Family history Child Triglycerides business.industry Cholesterol HDL Premature coronary artery disease Odds ratio Cholesterol LDL medicine.disease Obesity Lipids Blood pressure Cholesterol Child Preschool Pediatrics Perinatology and Child Health Female business Body mass index Dyslipidemia Biomarkers |
| Zdroj: | Jornal de pediatria. 80(2) |
| ISSN: | 0021-7557 |
| Popis: | Objectives: To identify the prevalence of dyslipidemia in a group of 109 children and adolescentswith a family history of premature coronary artery disease and to investigate the association betweendyslipidemia and other risk factors for atherosclerosis.Methods: Total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoproteincholesterol (HDL-C), triglycerides, body mass index, blood pressure, physical activity, smoking, percapita income and maternal schooling were investigated.Results: Total cholesterol and LDL-C levels were higher than desirable in 27.5% and 19.3%,respectively, of our patients; 13.8% had lower HDL-C values and 13.0% presented hypertriglyceridemia.Obesity and excess weight were observed in 25.7% of the cases. Out of these, 57.1% had abnormal lipidvalues. Dyslipidemia was observed in 38.5%, either alone or in combination with other risk factors.Smoking was observed in 3.6%, hypertension in 2.7% and physical inactivity in 72.5%. There was norelationship between dyslipidemia and per capita income, maternal schooling and physical inactivity.However, obesity and excess weight were identified as significantly associated with the occurrence ofdyslipidemia (p = 0.02; odds ratio = 2.82, 95% CI = 1.6-6.81).Conclusion: In children and adolescents with a family history of premature coronary artery disease,early identification of the risk factors for atherosclerosis is essential to allow the implementation ofpreventive measures.J Pediatr (Rio J). 2004;80(2):135-40: Hypercholesterolemia, dyslipidemia, coronary artery disease,atherosclerosis, lipoproteins. |
| Databáze: | OpenAIRE |
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