Pregnancy-associated malaria affects toll-like receptor ligand-induced cytokine responses in cord blood
| Autor: | Carsten Köhler, Lucja A. Labuda, Adrian J. F. Luty, Lutz P. Breitling, Saadou Issifou, Eveline Weerdenburg, Peter G. Kremsner, Sanders K. Chai, Dorrith Schonkeren, Ayola A. Adegnika, Selidji T Agnandji, Maria Yazdanbakhsh |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Population Ligands Immune system Immunity Pregnancy parasitic diseases medicine Immunology and Allergy Birth Weight Humans Pregnancy Complications Infectious education Pregnancy-associated malaria Toll-like receptor education.field_of_study Innate immune system biology Toll-Like Receptors Infant Newborn Plasmodium falciparum biology.organism_classification medicine.disease Fetal Blood Malaria Parity Infectious Diseases Immunology Cytokines Female |
| Zdroj: | The Journal of infectious diseases. 198(6) |
| ISSN: | 0022-1899 |
| Popis: | BACKGROUND: Pregnancy-associated malaria is known to modify fetal immunity. Most previous studies have been cross-sectional in nature and have focused on the priming of acquired immune responses in utero. In this context, the influence of the timing and/or duration of placental infection with Plasmodium falciparum are unknown, and changes to innate immune responses have not been studied extensively. METHODS: Pregnant women in Gabon, where P. falciparum infection is endemic, were followed up through monthly clinical and parasitological examinations from the second trimester to delivery. Cells of neonates born to mothers who had acquired P. falciparum infection |
| Databáze: | OpenAIRE |
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