Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

Autor:	Broekgaarden, M., Van Vught, R., Oliveira, Sabrina, Roovers, R. C., Van Bergen En Henegouwen, P. M P, Pieters, R. J., Van Gulik, T. M., Breukink, E., Heger, M., Membrane Biochemistry and Biophysics, Medicinal Chemistry and Chemical Biology, Celbiologie, Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Sub Cell Biology, Sub Drug delivery, Sub Medicinal Chemistry & Chemical biol.
Přispěvatelé:	AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, 02 Surgical specialisms, CCA -Cancer Center Amsterdam, Membrane Biochemistry and Biophysics, Medicinal Chemistry and Chemical Biology, Celbiologie, Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Sub Cell Biology, Sub Drug delivery, Sub Medicinal Chemistry & Chemical biol.
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Indoles medicine.medical_treatment Photodynamic therapy 02 engineering and technology Isoindoles Photochemistry 03 medical and health sciences Mice 0302 clinical medicine Materials Science(all) Cell Line Tumor Taverne medicine Organometallic Compounds Animals Humans General Materials Science Photosensitizer Zinc phthalocyanine Liposome Drug Carriers Photosensitizing Agents biology Chemistry Photosensitizing Agent Single-Domain Antibodies 021001 nanoscience & nanotechnology Oxygen Kinetics Zinc Nanomedicine Photochemotherapy Zinc Compounds 030220 oncology & carcinogenesis Liposomes biology.protein Cancer research Antibody 0210 nano-technology Drug carrier
Zdroj:	Nanoscale, 8(12), 6490-6494. Royal Society of Chemistry Nanoscale, 8(12), 6490. Royal Society of Chemistry
ISSN:	2040-3372 2040-3364
Popis:	Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64185e2e877f2a35083c24d763e8495f https://pure.amc.nl/en/publications/sitespecific-conjugation-of-single-domain-antibodies-to-liposomes-enhances-photosensitizer-uptake-and-photodynamic-therapy-efficacy(4cf8c98a-4316-4667-8056-7bbb3bf098b5).html Zobrazit plný text záznamu