Diversity of germ-line immunoglobulin VH genes
| Autor: | Rina Zakut, Daniela Ram, Justus B. Cohen, Kim Effron, David Givol, Gideon Rechavi |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Recombination
Genetic Genetics Signal peptide Multidisciplinary Base Sequence Base pair Immunoglobulin Variable Region Intron Antibody Diversity Biology Biological Evolution Molecular biology Stop codon Hypervariable region Mice Open reading frame Genes Animals Binding Sites Antibody Protein Precursors Immunoglobulin Heavy Chains Gene |
| Zdroj: | Nature. 292:426-430 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/292426a0 |
| Popis: | The sequences of four embryonic mouse immunoglobulin VH genes have been compared. All genes end at codon 98 and code for a hydrophobic signal peptide of 19 residues interrupted at codon -4 by an intron of 83 base pairs. Substitutions occur in all gene segments but at a significantly higher frequency in the hypervariable regions. The data suggest an evolutionary basis for the diversity of immunoglobulin genes. Divergence resulted also in a termination codon in two of the genes, suggesting that part of the V gene repertoire cannot be expressed unless some correction mechanism is available. |
| Databáze: | OpenAIRE |
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