A COMPARISON OF THE GLYCOSAMINOGLYCANS OF WEIGHT-BEARING AND NON-WEIGHT BEARING HUMAN DERMIS
| Autor: | Micheal H. Flint, Paul G. Bell-booth, Helen C. Reilly, Gerald C. Gillard |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Adolescent Dermatan Sulfate Human skin Dermatology Non weight bearing medicine.disease_cause Biochemistry Weight-bearing Glycosaminoglycan Dermis Pressure medicine Humans Hyaluronic Acid Child Molecular Biology Aged Glycosaminoglycans Skin Foot Chemistry Hexuronic Acids Chondroitin Sulfates Proteolytic enzymes Cell Biology Middle Aged Toes carbohydrates (lipids) medicine.anatomical_structure Child Preschool Keratins Female Heel |
| Zdroj: | Journal of Investigative Dermatology. 69(2):257-261 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12506406 |
| Popis: | Twenty-six samples of human skin from three non-weight-bearing and 27 samples from three weight-bearing sites were obtained at autopsy from 11 subjects varying in age from 4 to 91 years. The dermis was idssected free of other tissues and after proteolytic digestion, the glycosaminoglycans were isolated quantitatively by ion-exchange chromatography. Analysis of the preparations showed that there was significantly more glycosaminoglycan in the dermis from weight-bearing sites (p less than 0.001). The major glycosaminoglycans were hyaluronic acid and dermatan sulfate with chondroitin sulfate as a minor component, but the relative proportions of these components were not significantly different in the two sets of samples (p greater than 0.1). It is suggested that the quantity of glycosaminoglycan in the dermis is influenced by the functional requirements of the dermis at that site. |
| Databáze: | OpenAIRE |
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