High frequency of primary mutations associated with antiretroviral drug resistance in recently diagnosed HIV-infected children
| Autor: | Silvia González Ayala, Jorge Quarleri, Vera Giraudi, María Rosa Agosti, Graciela Barboni, Moira Vignoles, Mariel García, Horacio Salomón |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Anti-HIV Agents Population Molecular Sequence Data Antiretroviral drug HIV Infections Acquired immunodeficiency syndrome (AIDS) Immunopathology Antiretroviral Therapy Highly Active Drug Resistance Viral medicine Humans Pharmacology (medical) Prospective Studies Sida education Child Pharmacology education.field_of_study biology business.industry HIV Infant biology.organism_classification medicine.disease CD4 Lymphocyte Count Infectious Diseases El Niño Child Preschool Mutation Female Viral disease business HIV drug resistance |
| Zdroj: | Antiviral therapy. 12(7) |
| ISSN: | 1359-6535 |
| Popis: | IntroductionThe aim of our study was to analyse the frequency of primary mutations associated with HIV drug resistance in a population of children born to HIV-infected mothers.DesignA prospective study included newly HIV-diagnosed children treated at two public paediatric hospitals.Patients and methodsClinical and antiretroviral therapy (ART) data were collected in mother-child pairs. HIV-1 subtyping and ART resistance mutations were assayed in children by sequencing a region of HIV pol gene.Results: A total of 67 children were enrolled22 less than 12 months of age, 20 between 1 and 5 years and 25 between 6 and 14 years. Six (9.0%) children had viral strains with at least one primary mutation associated with resistance to reverse transcriptase and protease inhibitors. A significantly ( P=0.019) higher frequency of resistance (22.7%, n=5/22) was found among children aged DiscussionA high percentage of recently diagnosed infants were found to carry primary ART resistance mutations. Limited options for ART of HIV-infected children might lead to increased HIV-associated morbidity and mortality. Thus, consideration should be given to mandatory screening for primary ART resistance before initiating therapy for infants aged |
| Databáze: | OpenAIRE |
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