Progesterone implants enhance SIV vaginal transmission and early virus load
| Autor: | Peter J. Dailey, Preston A. Marx, David D. Ho, Nancy J. Alexander, Ronald S. Veazey, Christopher J. Miller, A I Spira, C J Mahoney, Andrew A. Lackner, A Gettie, L E Claypool |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
viruses
media_common.quotation_subject Simian Acquired Immunodeficiency Syndrome Antibodies Viral medicine.disease_cause Epithelium General Biochemistry Genetics and Molecular Biology Andrology Proviruses Follicular phase medicine Animals Sex organ Viremia Virus load Progesterone Menstrual cycle media_common Drug Implants Lamina propria Mucous Membrane biology Transmission (medicine) General Medicine Simian immunodeficiency virus Macaca mulatta medicine.anatomical_structure Follicular Phase DNA Viral Vagina Immunology Disease Progression Leukocytes Mononuclear biology.protein Female Simian Immunodeficiency Virus Disease Susceptibility Antibody |
| Zdroj: | Nature Medicine. 2:1084-1089 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/nm1096-1084 |
| Popis: | Simian immunodeficiency virus (SIV) can cross the intact vaginal epithelium to establish a systemic infection in macaques (mac). Using this SIVmac model, we found that subcutaneous progesterone implants, which could mimic hormonally based contraceptives, thinned the vaginal epithelium and enhanced SIV vaginal transmission 7.7-fold over that observed in macaques treated with placebo implants and exposed to SIV in the follicular phase of the menstrual cycle. Progesterone treatment also increased the number of SIV DNA-positive cells in the vaginal lamina propria as detected by in situ polymerase chain reaction analysis. Moreover, plasma viral RNA was elevated for the first three months in macaques with progesterone implants, and three of the progesterone-treated macaques developed relatively rapid disease courses. This study shows that SIV genital infection and disease course are enhanced by subcutaneous implants containing progesterone when compared with the rate of vaginal transmission in the follicular phase. |
| Databáze: | OpenAIRE |
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