Lipidomic and Antioxidant Response to Grape Seed, Corn and Coconut Oils in Healthy Wistar Rats
| Autor: | Laura A. de la Rosa, Belinda Vallejo-Cordoba, Gilberto Mercado-Mercado, José Alberto López-Díaz, Rogelio González-Arellanes, Gustavo A. González-Aguilar, Abraham Wall-Medrano, Alma A. Vazquez-Flores, Aarón F. González-Córdova, Francisco Javier Molina-Corral |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine antioxidant Antioxidant HDL phytosterols corn oil fatty acids specialty oil grapeseed oil coconut oil lipoproteins medicine.medical_treatment Antioxidants Random Allocation Vitis Food science Grape seed chemistry.chemical_classification Nutrition and Dietetics Phytosterol Coconut oil Specific Pathogen-Free Organisms Liver Biochemistry Mrna level Seeds lcsh:Nutrition. Foods and food supply food.ingredient Hyperlipidemias lcsh:TX341-641 Antioxidant response element Article 03 medical and health sciences food Dietary Fats Unsaturated Phenols medicine Animals Plant Oils Rats Wistar Oxygen Radical Absorbance Capacity 030109 nutrition & dietetics Cholesterol HDL Fatty acid Lipid Metabolism Gene Expression Regulation chemistry Biomarkers Corn oil Food Science |
| Zdroj: | Nutrients; Volume 9; Issue 1; Pages: 82 Nutrients, 9(1):82 Nutrients, Vol 9, Iss 1, p 82 (2017) Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu9010082 |
| Popis: | Specialty oils differ in fatty acid, phytosterol and antioxidant content, impacting their benefits for cardiovascular health. The lipid (fatty acid, phytosterol) and antioxidant (total phenolics, radical scavenging capacity) profiles of grapeseed (GSO), corn (CO) and coconut (CNO) oils and their physiological (triacylglycerides, total and HDL-cholesterol and antioxidant capacity (FRAP) in serum and fatty acid and phytosterol hepatic deposition) and genomic (HL, LCAT, ApoA-1 and SR-BP1 mRNA hepatic levels) responses after their sub-chronic intake (10% diet for 28 days) was examined in healthy albino rats. Fatty acid, phytosterol and antioxidant profiles differed between oils (p ≤ 0.01). Serum and hepatic triacylglycerides and total cholesterol increased (p ≤ 0.01); serum HDL-Cholesterol decreased (p < 0.05); but serum FRAP did not differ (p > 0.05) in CNO-fed rats as compared to CO or GSO groups. Hepatic phytosterol deposition was higher (+2.2 mg/g; p ≤ 0.001) in CO- than GSO-fed rats, but their fatty acid deposition was similar. All but ApoA-1 mRNA level increased in GSO-fed rats as compared to other groups (p ≤ 0.01). Hepatic fatty acid handling, but not antioxidant response, nor hepatic phytosterol deposition, could be related to a more efficient reverse-cholesterol transport in GSO-fed rats as compared to CO or CNO. |
| Databáze: | OpenAIRE |
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