Double-blind placebo-controlled trial of corticosteroids in children with postpericardiotomy syndrome
| Autor: | Steven A. Webber, George G.S. Sandor, Marion Tipple, Nigel J. Wilson, Jacques G. LeBlanc, Michael W.H. Patterson |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Placebo-controlled study Placebo Pericardial effusion Pericardial Effusion law.invention Double-Blind Method Randomized controlled trial Adrenal Cortex Hormones law Prednisone Humans Medicine Child business.industry Infant Postpericardiotomy syndrome Prognosis medicine.disease Cardiac surgery Surgery Clinical trial Treatment Outcome Echocardiography Child Preschool Pericardiectomy Anesthesia Pediatrics Perinatology and Child Health Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1432-1971 0172-0643 |
| Popis: | The objective of this study was to assess the efficacy of corticosteroids in hastening the recovery of children with postpericardiotomy syndrome, using a randomized double-blind placebo-controlled trial in a tertiary care referral center for pediatric cardiology and cardiac surgery. Twenty-one children, 6 months of age or older (mean age 3.9 years) with postpericardiotomy syndrome following open or closed heart surgery were administered either prednisone 2 mg/kg/day reducing to zero over 14 days (n = 12) or placebo (n = 9). Progress was monitored by daily clinical assessment and alternate day cross-sectional echocardiograms. The primary measures of efficacy were the number of patients in remission at 72 h and at 1 week. No difference in remission rates were found at 72 h, but at 1 week significantly more children treated with prednisone were in remission (placebo 3/9; prednisone 10/12, p = 0.03). A trend to faster resolution of all symptoms and signs was seen in the prednisone-treated group but this was not associated with earlier hospital discharge. Enlargement of pericardial effusion was seen in two children treated with steroids. No complications of treatment were encountered. Prednisone hastens the recovery of children with postopericardiotomy syndrome. Pericardial effusions may increase in size despite the use of corticosteroids. |
| Databáze: | OpenAIRE |
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