Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates

Autor:	H. E. Van Wart, Keith A. M. Walker, Sharon M. Dankwardt, Leslie A. Robinson, Robert L. Martin, Dean M. Wilson, R.W. Sullivan, Nancy G. J. Delaet, E.K. Bradley
Rok vydání:	2003
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Carboxamide Diamino acid Hydroxamic Acids Biochemistry Chemical synthesis Bone Morphogenetic Protein 1 chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Protease Inhibitors Molecular Biology chemistry.chemical_classification Hydroxamic acid biology Bicyclic molecule Organic Chemistry Metalloendopeptidases Procollagen peptidase Kinetics Enzyme chemistry Enzyme inhibitor Bone Morphogenetic Proteins biology.protein Molecular Medicine Indicators and Reagents
Zdroj:	Bioorganicmedicinal chemistry letters. 13(13)
ISSN:	0960-894X
Popis:	The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the d -diaminopropionic acid derivatives were shown to be single digit nanomolar PCP inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64121e9fba0f8898d0489756f26a7e04 https://pubmed.ncbi.nlm.nih.gov/12798313 Zobrazit plný text záznamu Full Text from ScienceDirect