Clozapine and mortality: A comparison with other antipsychotics in a nationwide Danish cohort study

Autor: Jimmi Nielsen, Jean-Paul Selten, Yvonne van der Zalm, Iris E. C. Sommer, Fabian Termorshuizen, Leslie Foldager
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Movement Disorder (MD), Clinical Cognitive Neuropsychiatry Research Program (CCNP), RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Acta Psychiatrica Scandinavica, 143(3), 216-226. Wiley
Zalm, Y, Foldager, L, Termorshuizen, F, Sommer, I E, Nielsen, J & Selten, J 2021, ' Clozapine and mortality: A comparison with other antipsychotics in a nationwide Danish cohort study ', Acta Psychiatrica Scandinavica, vol. 143, no. 3, pp. 216-226 . https://doi.org/10.1111/acps.13267
van der Zalm, Y C, Foldager, L, Termorshuizen, F, Sommer, I E, Nielsen, J & Selten, J-P 2021, ' Clozapine and mortality : A comparison with other antipsychotics in a nationwide Danish cohort study ', Acta Psychiatrica Scandinavica, vol. 143, no. 3, pp. 216-226 . https://doi.org/10.1111/acps.13267
Acta Psychiatrica Scandinavica
ISSN: 0001-690X
Popis: Objective To compare the mortality in people using clozapine to that of people using other antipsychotics. Methods Danish incidence cohort of 22 110 patients with a first diagnosis of non-affective psychotic disorder (1995-2013) and a prevalence cohort of 50 881 patients ever diagnosed with such a disorder (1969-2013). Hazard ratios (HR) were calculated for the antipsychotic drug used at the time of death (?current use?: incidence and prevalence cohort), and for the drug used for the longest at that moment (?cumulative use?: incidence cohort), using a Cox model with adjustment for somatic comorbidity. Clozapine was the reference drug. Results As for current drug use, the risk of suicide was higher among users of other antipsychotics in the incidence (HRadj=1.76; 95% CI 0.72-4.32) and prevalence (HRadj=2.20; 95% CI 1.35-3.59) cohorts. There was no significant difference in all-cause or cardiovascular mortality in the two cohorts. Cumulative use of clozapine was not associated with an increased cardiovascular mortality. Cumulative use of other antipsychotics for up to 1 year was associated with a lower all-cause mortality and suicide risk than a similar period of clozapine use (all-cause: HRadj=0.73; 95% CI 0.63-0.85, suicide; HRadj=0.65; 95% CI 0.46-0.91). Conclusion The results indicate that the use of clozapine is not associated with increased cardiovascular mortality. We found opposing trends towards a lower risk of suicide during current use of clozapine and a higher risk of suicide associated with cumulative use up to 1 year. This suggests that clozapine cessation marks a period of high risk of suicide. ObjectiveTo compare the mortality in people using clozapine to that of people using other antipsychotics.Methods Danish incidence cohort of 22 110 patients with a first diagnosis of non‐affective psychotic disorder (1995‐2013) and a prevalence cohort of 50 881 patients ever diagnosed with such a disorder (1969‐2013). Hazard ratios (HR) were calculated for the antipsychotic drug used at the time of death (‘current use’: incidence and prevalence cohort), and for the drug used for the longest at that moment (‘cumulative use’: incidence cohort), using a Cox model with adjustment for somatic comorbidity. Clozapine was the reference drug.Results As for current drug use, the risk of suicide was higher among users of other antipsychotics in the incidence (HRadj=1.76; 95% CI 0.72‐4.32) and prevalence (HRadj=2.20; 95% CI 1.35‐3.59) cohorts. There was no significant difference in all‐cause or cardiovascular mortality in the two cohorts. Cumulative use of clozapine was not associated with an increased cardiovascular mortality. Cumulative use of other antipsychotics for up to 1 year was associated with a lower all‐cause mortality and suicide risk than a similar period of clozapine use (all‐cause: HRadj=0.73; 95% CI 0.63‐0.85, suicide; HRadj=0.65; 95% CI 0.46‐0.91).Conclusion The results indicate that the use of clozapine is not associated with increased cardiovascular mortality. We found opposing trends towards a lower risk of suicide during current use of clozapine and a higher risk of suicide associated with cumulative use up to 1 year. This suggests that clozapine cessation marks a period of high risk of suicide.
Databáze: OpenAIRE
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