Sarcopenia in patients after an episode of acute decompensated heart failure: An underdiagnosed problem with serious impact

Autor: Stefan D. Anker, Ruddy Richard, Guillaume Clerfond, Yves Boirie, Pierre-Louis Tartière, Clément Riocreux, Patrick Rossignol, Bruno Pereira, Géraud Souteyrand, Nicolas Combaret, Marie Blanquet, Marie-Claire D'Agrosa Boiteux, Pascal Motreff, Aurélien Mulliez, Pelle Stolt, Frédéric Jean, Romain Eschalier, Grégoire Massoullié
Přispěvatelé: CHU Clermont-Ferrand, SIGMA Clermont (SIGMA Clermont), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, CH Mauriac, Biostatistics Unit (Department of Clinical Research and Innovation), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Clinique Médicale Cardio-Pneumologie de Durtol, Maglia Rotta, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), ROSSI, Sabine, Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Sarcopenia
Longitudinal study
medicine.medical_specialty
Acute decompensated heart failure
Decompensated chronic heart failure
030209 endocrinology & metabolism
Decompensation
Critical Care and Intensive Care Medicine
03 medical and health sciences
0302 clinical medicine
Internal medicine
Activities of Daily Living
Prevalence
Humans
Medicine
In patient
Longitudinal Studies
Prospective Studies
Aged
Aged
80 and over
Heart Failure
030109 nutrition & dietetics
Nutrition and Dietetics
Hand Strength
business.industry
musculoskeletal system
medicine.disease
Chronic heart failure
3. Good health
Hospitalization
body regions
Clinical trial
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
Cross-Sectional Studies
Dysmobility
Cohort
Female
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
human activities
Zdroj: Clinical Nutrition
Clinical Nutrition, 2021, 40 (6), pp.4490-4499. ⟨10.1016/j.clnu.2020.12.033⟩
ISSN: 0261-5614
DOI: 10.1016/j.clnu.2020.12.033
Popis: International audience; Background & aims: Sarcopenia is a multifactorial syndrome resulting in a decrease in both muscle mass and function. Little is known about the prevalence and prognostic impact of sarcopenia in patients with acutely decompensated chronic heart failure (ADHF). We aimed to evaluate the prevalence (main endpoint) and impact of sarcopenia on ADHF patients.Methods: 140 ADHF patients were enrolled between November 2014 and September 2018 in a multi-center prospective longitudinal study. A similar, independent multi-departmental cross-sectional study in 165 ADHF patients was used for external validation of prevalence data. All subjects were assessed on the European Working Group on Sarcopenia criteria.Results: Ninety-one patients (65%) had sarcopenia (vs. 53.6% in the external replication regional cohort). Patients with sarcopenia were older and more likely to have eGFR
Databáze: OpenAIRE
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