Synaptic Encoding of Fear Memories in the Amygdala
| Autor: | Stephen Maren, Reed L. Ressler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Interneuron Conditioning Classical Stimulus (physiology) Amygdala Article Extinction Psychological 03 medical and health sciences 0302 clinical medicine Neurochemical Interneurons Memory medicine Animals Humans Fear conditioning Neuronal Plasticity General Neuroscience Fear Content-addressable memory 030104 developmental biology medicine.anatomical_structure Synaptic plasticity Synapses Excitatory postsynaptic potential Psychology Neuroscience 030217 neurology & neurosurgery |
| Popis: | Over the years Pavlovian fear conditioning has proved to be a powerful model to investigate the neural underpinnings of aversive associative memory formation. Although it is well appreciated that plasticity occurring at excitatory synapses within the basolateral complex of the amygdala (BLA) plays a critical role in associative memory formation, recent evidence suggests that plasticity within the amygdala is more distributed than previously appreciated. In particular, studies demonstrate that plasticity in the central nucleus (CeA) is critical for the acquisition of conditioned fear. In addition, a variety of interneuron populations within the amygdala, defined by unique neurochemical markers, contribute to distinct aspects of stimulus processing and memory formation during fear conditioning. Here, we will review and summarize recent advances in our understanding of amygdala networks and how unique players within this network contribute to synaptic plasticity associated with the acquisition of conditioned fear. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|