Allo-non-specific elevation of maternal killer cell activity in intrauterine growth restriction
| Autor: | Yoichi Shibata, Tomoyuki Fujii, Ruriko Tsushima, Yuji Taketani, Takashi Okai |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Cell Intrauterine growth restriction chemical and pharmacologic phenomena Umbilical cord Pathogenesis Pregnancy Internal medicine medicine Humans Cytotoxic T cell Killer Cells Lymphokine-Activated Cells Cultured reproductive and urinary physiology Fetus Fetal Growth Retardation Lymphokine-activated killer cell business.industry Lymphokine Obstetrics and Gynecology General Medicine Cytotoxicity Tests Immunologic medicine.disease female genital diseases and pregnancy complications Endocrinology medicine.anatomical_structure embryonic structures Female business T-Lymphocytes Cytotoxic |
| Zdroj: | International Journal of Gynecology & Obstetrics. 52:237-242 |
| ISSN: | 0020-7292 |
| DOI: | 10.1016/0020-7292(95)02609-6 |
| Popis: | Objective: In order to gain insight into the pathogenesis of intrauterine growth restriction (IUGR) of the fetus, we evaluated the cytotoxic activity of lymphocytes towards fetal cells in pregnancies complicated by IUGR. Methods: We performed a cytotoxic assay using the maternal lymphocyte-derived lymphokine activated killer (LAK) cells as the effector cells. Cord vessel endothelial cells were used as the target cells. Results: LAK cells in pregnancies complicated by IUGR demonstrated higher killer cell activities against IUGR fetus-derived endothelial cells compared with LAK cells from uncomplicated pregnancies against the same endothelial cells. However, when non-IUGR fetus-derived endothelial cells were used as the target cells, LAK cells of pregnant women with IUGR exhibited essentially the same activities as those of normal pregnant women. Conclusion: The results suggest that lymphocytes in pregnancies complicated by IUGR may have enhanced killer cell activities towards the IUGR fetus in an allo-non-specific way. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text