Nitrogen atom insertion into indenes to access isoquinolines

Autor:	Patrick Finkelstein, Julia C. Reisenbauer, Bence B. Botlik, Ori Green, Andri Florin, Bill Morandi
Rok vydání:	2023
Předmět:	General Chemistry
Zdroj:	Chemical Science, 14 (11)
ISSN:	2041-6539 2041-6520
Popis:	We report a convenient protocol for a nitrogen atom insertion into indenes to afford isoquinolines. The reaction uses a combination of commercially available phenyliodine(III) diacetate (PIDA) and ammonium carbamate as the nitrogen source to furnish a wide range of isoquinolines. Various substitution patterns and commonly used functional groups are well tolerated. The operational simplicity renders this protocol broadly applicable and has been successfully extended towards the direct interconversion of cyclopentadienes into the corresponding pyridines. Furthermore, this strategy enables the facile synthesis of 15N labelled isoquinolines, using 15NH4Cl as a commercial 15N source. Chemical Science, 14 (11) ISSN:2041-6520 ISSN:2041-6539
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640b8fb05323d30b4700ae783c0149e7 https://doi.org/10.1039/d2sc06952k Zobrazit plný text záznamu