Two groups of rhinoviruses revealed by a panel of antiviral compounds present sequence divergence and differential pathogenicity
| Autor: | Henri Moereels, J. Snoeks, P. A. J. Janssen, Leo Wouters, Pj Lewi, B. Dewindt, Koenraad Jozef Lodewijk Marcel Andries |
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| Rok vydání: | 1990 |
| Předmět: |
Serotype
Rhinovirus viruses Molecular Sequence Data Immunology Sequence alignment Biology medicine.disease_cause Antiviral Agents Microbiology Group A Virus Capsid stomatognathic system Sequence Homology Nucleic Acid Virology medicine Amino Acid Sequence Binding site Peptide sequence chemistry.chemical_classification Analysis of Variance Binding Sites Virulence virus diseases Amino acid Poliovirus chemistry Insect Science Research Article |
| Zdroj: | Journal of Virology. 64:1117-1123 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | A variety of chemically different compounds inhibit the replication of several serotypes of rhinoviruses (common-cold viruses). We noticed that one of these antiviral compounds, WIN 51711, had an antiviral spectrum clearly distinctive from a consensus spectrum or other capsid-binding compounds, although all of them were shown to share the same binding site. A systematic evaluation of all known rhinovirus capsid-binding compounds against all serotyped rhinoviruses was therefore initiated. Multivariate analysis of the results revealed the existence of two groups of rhinoviruses, which we will call antiviral groups A and B. The differential sensitivity of members of these groups to antiviral compounds suggests the existence of a dimorphic binding site. The antiviral groups turned out to be a reflection of a divergence of rhinovirus serotypes on a much broader level. Similarities in antiviral spectra were highly correlated with sequence similarities, not only of amino acids lining the antiviral compound-binding-site, but also of amino acids of the whole VP1 protein. Furthermore, analysis of epidemiological data indicated that group B rhinoviruses produced more than twice as many clinical infections per serotype than group A rhinoviruses did. Rhinoviruses belonging to the minor receptor group were without exception all computed to lie in the same region of antiviral group B. |
| Databáze: | OpenAIRE |
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