Low uric acid level increases the risk of infectious mononucleosis and this effect is more pronounced in women
Autor: | Qiyu Jia, Xue Li, Pingping Zhou, Zhaowei Meng, Qiang Jia, Lu Gong, Kun Song, Chongjie Pang, Qing Zhang, Tianpeng Hu, Jian Tan, Li Zhang, Na Liu |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Receiver operating characteristic Mononucleosis Curve analysis Odds ratio Articles Biology Logistic regression medicine.disease Gastroenterology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Oncology Quartile chemistry Internal medicine Immunology medicine Uric acid Binary logistic regression analysis 030217 neurology & neurosurgery |
Popis: | Infectious mononucleosis (IM) due to Epstein-Barr virus infection is common. Uric acid (UA) is an important endogenous antioxidant. To the best of our knowledge, the association between UA and IM has not been comprehensively investigated to date. The aim of the present study was to investigate this association in Chinese patients. A total of 95 patients (47 men and 48 women) with IM were recruited, along with 95 healthy controls. Clinical data were classified by patient sex. Receiver operating characteristic (ROC) curve analysis was adopted to determine the cut-off values of UA for IM diagnosis and prediction. Crude and adjusted odds ratios (ORs) of UA for IM were analyzed by binary logistic regression. The UA levels were significantly lower in IM patients compared with those in controls. In addition, UA levels in men were significantly higher compared with those in women. The ROC curve demonstrated good diagnostic and predictive values of UA for IM in both sexes. The UA cut-off values were 326.00 and 243.50 µmol/l for diagnosing IM in men and women, respectively, with a diagnostic accuracy of 76.596 and 80.208%, respectively. Binary logistic regression analysis revealed a significant risk of IM in the low UA quartiles in both sexes. Following adjustments, the ORs even increased. Women with low UA levels appeared to be more susceptible to IM. For example, the crude ORs in quartile 1 were 24.000 and 52.500 for men and women, respectively, and the respective adjusted ORs were 31.437 and 301.746 (all P |
Databáze: | OpenAIRE |
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