Enzymatic Synthesis of (R)-Flurbiprofen
| Autor: | Hiromichi Ohta, Yoichiro Ijima, Hitoshi Kakidani, Yosuke Terao |
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| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Bulletin of the Chemical Society of Japan. 76:2395-2397 |
| ISSN: | 1348-0634 0009-2673 |
| DOI: | 10.1246/bcsj.76.2395 |
| Popis: | α-Methyl-α-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen) was prepared from the corresponding malonic acid derivative via asymmetric decarboxylation catalyzed by an enzyme, arylmalonate decarboxylase (EC 4.1.1.76), in high chemical and optical yields. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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