Macrophage-derived chemokine in malignant and tuberculous pleural effusions
| Autor: | Masataka Shibazaki, Kazuyoshi Imaizumi, Kenzo Takagi, Yoshinori Hasegawa, Tsutomu Kawabe, Naozumi Hashimoto, Atsushi Sumida, Kaoru Shimokata, Masakazu Okamoto |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Chemokine Lung Neoplasms Tuberculosis Pleural effusion Th2 Cells Humans Medicine Malignant pleural effusion Volume concentration Aged Aged 80 and over Chemokine CCL22 Antitumor immunity biology business.industry Tuberculosis Pleural Middle Aged respiratory system medicine.disease Pleural Effusion Malignant respiratory tract diseases Chemokines CC biology.protein Female business CCL22 Macrophage-Derived Chemokine |
| Zdroj: | Respirology. 12:581-584 |
| ISSN: | 1440-1843 1323-7799 |
| DOI: | 10.1111/j.1440-1843.2007.01059.x |
| Popis: | Background and objectives: Macrophage-derived chemokine (MDC/CCL22) is recognized as a T-helper (Th) 2-type chemokine. Both malignant and tuberculous pleural effusions are typically lymphocytic pleural effusions. Tuberculous pleural effusions have a more polarized Th1 reaction than malignant effusions, which are predominantly Th2 in nature. The aim of this study was to compare the levels of MDC in malignant pleural effusions with those in tuberculous pleural effusions to help delineate the role of MDC in Th2 versus Th1 effusions. Methods: Forty-three patients with pleural effusions (32 malignant, 11 tuberculous) were studied. The concentration of MDC in the pleural effusion was measured by ELISA. Results: The median concentration of MDC was lower in malignant pleural effusions than in tuberculous pleural effusions (P |
| Databáze: | OpenAIRE |
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