Supraclavicular lymph node recurrence after radical surgery: is epidermal growth factor receptor a predictive marker?
| Autor: | Ning Li, Wen-Xuan Wang, J.J. Wu, Canhua Jiang, Xinqun Chen, Ya-Qin Hu, L.W. Ma, X. Gao, Jingfei Chen, An-jie Min |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Metastasis Tongue Internal medicine medicine Humans Epidermal growth factor receptor Radical surgery Predictive marker biology business.industry medicine.disease Prognosis Supraclavicular lymph nodes ErbB Receptors medicine.anatomical_structure Otorhinolaryngology Cervical lymph nodes Lymphatic Metastasis biology.protein Carcinoma Squamous Cell Surgery Mouth Neoplasms Lymph Lymph Nodes Oral Surgery business |
| Zdroj: | International journal of oral and maxillofacial surgery. 51(5) |
| ISSN: | 1399-0020 |
| Popis: | The aim of this study was to evaluate the rare postoperative supraclavicular metastasis originating from oral squamous cell carcinoma (OSCC) and to discuss epidermal growth factor receptor (EGFR) as a potential predictive marker. Tumour specimens of OSCC patients divided into three groups were included: supraclavicular metastasis (n = 8), conventional cervical metastasis (n = 28), no metastasis (n = 48). Basic information and EGFR expression were compared among these groups and the data were analysed to identify potentially related risk factors for supraclavicular metastasis. In the supraclavicular metastasis group (n = 8), all primary tumours were T1-T2 and located in the tongue and buccal region; five of eight cases were pathologically N0. The median interval from the primary tumour resection to the development of supraclavicular metastases was 21.5 months. All related deaths (5/8) occurred within 2 years. In the supraclavicular metastasis group, EGFR expression was highest in the supraclavicular metastases, followed by cervical lymph nodes, and was lowest in the primary tumours (P = 0.39). In contrast, in the conventional metastasis group and the N0 group, EGFR expression was higher in the primary tumours than in the lymph nodes (P < 0.01). Supraclavicular metastasis of OSCC is infrequent and associated with a poor prognosis. EGFR might predict the occurrence of supraclavicular metastasis. |
| Databáze: | OpenAIRE |
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