Extended spectrum β-lactamase-producing Enterobacteriaceae infection in heart and lung transplant recipients and in mechanical circulatory support recipients
| Autor: | Margrit Carlson, Kevin T. Bui, Seema Mehta, Abbas Ardehali, David Ross, Bernard M. Kubak, Joseph P. Lynch, Matthew Leibowitz, Joanna Schaenman, T. Khuu, Rajan Saggar |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.drug_class Klebsiella pneumoniae Urinary system Antibiotics beta-Lactamases Enterobacteriaceae Internal medicine medicine Humans Intensive care medicine Escherichia coli Infections Aged Retrospective Studies Transplantation Lung biology business.industry Incidence Enterobacteriaceae Infections Klebsiella oxytoca biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses biology.organism_classification medicine.disease Citrobacter freundii Klebsiella Infections Survival Rate Pneumonia medicine.anatomical_structure Bacteremia Heart Transplantation Female Heart-Assist Devices business Lung Transplantation |
| Zdroj: | Transplantation. 97(5) |
| ISSN: | 1534-6080 |
| Popis: | BACKGROUND Extended spectrum β-lactamase (ESBL)-producing gram-negative bacilli are increasingly reported in patients with a variety of risk factors including prior cephalosporin and antibiotic usage, prolonged hospitalizations, existence of comorbid conditions, and critical illness. METHODS Retrospective review of infections caused by ESBL-producing Enterobacteriaceae was performed in heart transplant (HTx), lung transplant (LTx), and mechanical circulatory support (MCS) device recipients at a large transplant center. RESULTS Among 1065 patients transplanted/implanted, the incidence of ESBL-related infections (bacteremia, urinary tract infections, pneumonia, central venous catheter-associated infection, and wound infections) in HTx, LTx, and MCS device recipients was reported at 2.2%, 5.5%, and 10.7%, respectively, caused by ESBL-producing Klebsiella pneumoniae, Escherichia coli, Klebsiella oxytoca, and Citrobacter freundii. CONCLUSIONS Early detection and adequate duration of therapy for ESBL-producing Enterobacteriaceae in solid organ transplants and MCS device recipients are essential in successful patient outcomes including prevention of recurrent infection. |
| Databáze: | OpenAIRE |
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