Protein-carbohydrate interaction effects on energy balance, FGF21, IGF-1, and hypothalamic gene expression in rats
| Autor: | Patrick C. Even, Claire Gaudichon, Catherine Chaumontet, Dalila Azzout-Marniche, Joséphine Gehring, Julien Piedcoq |
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| Přispěvatelé: | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Pro-Opiomelanocortin FGF21 Physiology [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism medicine.medical_treatment Hypothalamus Energy balance Gene Expression 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Low-protein diet Physiology (medical) Internal medicine Gene expression Dietary Carbohydrates medicine Animals Protein–carbohydrate interactions Agouti-Related Protein Insulin-Like Growth Factor I Rats Wistar 030304 developmental biology 2. Zero hunger Neurotransmitter Agents 0303 health sciences Chemistry Protein intake Rats Fibroblast Growth Factors Endocrinology Body Composition Energy intakes Dietary Proteins Energy Metabolism |
| Zdroj: | AJP-Endocrinology and Metabolism AJP-Endocrinology and Metabolism, American Physiological Society, In press, ⟨10.1152/ajpendo.00246.2021⟩ |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | International audience; Amino acids are involved in energy homeostasis, just as are carbohydrates and lipids. Therefore, mechanisms controlling protein intake should operate independently and in combination with systems controlling overall energy intake to coordinate appropriate metabolic and behavioural responses. The objective of this study was to quantify the respective roles of dietary protein and carbohydrate levels on energy balance, plasma FGF21 and IGF-1 concentrations, and hypothalamic neurotransmitters (POMC, NPY, AgRP and CART). In a simplified geometric framework, 7-week-old male Wistar rats were fed 12 diets containing 3 to 30% protein for 3 weeks, in which carbohydrates accounted for 30 to 75% of the carbohydrate and fat part of the diet. As a result of this study, most of the studied parameters (body composition, energy expenditure, plasma FGF21 and IGF-1 concentrations and Pomc/Agrp ratio) responded mainly to the protein content and to a lesser extent to the carbohydrate content in the diet. |
| Databáze: | OpenAIRE |
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