Post-translational Modifications of Centromeric Chromatin
| Autor: | Ana García del Arco, Sylvia Erhardt |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
biology Centromere Differential regulation Chromatin 3. Good health Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Histone chemistry Gene expression Posttranslational modification biology.protein Protein Processing Post-Translational Centromere Protein A DNA |
| Zdroj: | Progress in Molecular and Subcellular Biology Progress in Molecular and Subcellular Biology-Centromeres and Kinetochores Centromeres and Kinetochores ISBN: 9783319585918 Centromeres and Kinetochores |
| ISSN: | 0079-6484 2197-8484 |
| DOI: | 10.1007/978-3-319-58592-5_9 |
| Popis: | Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromatin regions bear their specific signature of histone modifications. The composition of centromeric chromatin is significantly different from other chromatin structures and mainly defined by the presence of the histone H3-variant CENP-A. Here we summarize the composition of centromeric chromatin and what we know about its differential regulation by post-translational modifications. |
| Databáze: | OpenAIRE |
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