Does glyceryl trinitrate cause central sympatholytic effects? Insights from a case of baroreflex failure
| Autor: | Stephen B. Harrap, Angelina Y. Fong, Andrew M. Allen, Seok Lim, Robert M. Anderson, Andrew Hammond, Sarah Tan, Lin Xie |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Sympathetic nervous system medicine.medical_specialty Sympathetic Nervous System Vasodilator Agents Blood Pressure Vasodilation 030204 cardiovascular system & hematology Baroreflex Nitroglycerin 03 medical and health sciences 0302 clinical medicine Heart Rate Sympatholytic Internal medicine Internal Medicine medicine Humans Tilt test cardiovascular diseases 030212 general & internal medicine Aged Nasopharyngeal Carcinoma business.industry Sympatholytic Effects medicine.anatomical_structure Blood pressure Hypertension cardiovascular system Cardiology Blood pressure lowering business circulatory and respiratory physiology |
| Zdroj: | Internal Medicine Journal. 50:114-117 |
| ISSN: | 1445-5994 1444-0903 |
| DOI: | 10.1111/imj.14699 |
| Popis: | Whether part of the blood pressure lowering effects of glyceryl trinitrate (GTN) is the result of centrally mediated reduction in sympathetic activity is debated. In humans, baroreflex activity potentially obscures the central sympatholytic effects of GTN. We examined this in a routine clinical tilt test in a patient with baroreflex failure secondary to previous neck radiotherapy. With reduced baroreflex function we observed an exaggerated fall in blood pressure and reduced sympathetic activity with GTN, supporting a peripheral vasodilation and central sympatholytic effect. |
| Databáze: | OpenAIRE |
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