The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p
| Autor: | Philippe Berta, Jean-Louis Bergé-Lefranc, Catherine Marsollier, Philippe Jay, Sylvie Taviaux, C Méjean |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Sequence analysis Molecular Sequence Data Protein domain Gene Expression Biology Proto-Oncogene Mas Homology (biology) Immediate-Early Proteins Complementary DNA Gene expression Genetics Humans RNA Messenger Cloning Molecular Growth Substances Molecular Biology In Situ Hybridization Fluorescence chemistry.chemical_classification Base Sequence Sequence Homology Amino Acid Nucleic acid sequence Chromosome Mapping Amino acid chemistry Chromosomes Human Pair 1 Intercellular Signaling Peptides and Proteins Sequence Alignment Immediate early gene Cysteine-Rich Protein 61 |
| Zdroj: | Oncogene. 14:1753-1757 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1200986 |
| Popis: | Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|