Ameliorative role of diets fortified with Curcumin in a Drosophila melanogaster model of aluminum chloride-induced neurotoxicity
| Autor: | Adegbuyi Oladele Aderibigbe, Kehinde D. Fasae, Amos O. Abolaji, Bolaji O. Oyetayo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Medicine (miscellaneous) Pharmacology 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Neurotoxicity medicine TX341-641 Hydrogen peroxide Curcumin-rich diets 030109 nutrition & dietetics Nutrition and Dietetics D. melanogaster integumentary system biology Nutrition. Foods and food supply Chemistry 04 agricultural and veterinary sciences Glutathione medicine.disease 040401 food science Oxidative stress Catalase Polyphenol Toxicity biology.protein Curcumin Aluminum Food Science |
| Zdroj: | Journal of Functional Foods, Vol 71, Iss, Pp 104035-(2020) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2020.104035 |
| Popis: | Aluminum is an environmental and industrial neurotoxicant known to induce oxidative damage and inflammation in tissues. Curcumin is a polyphenol with antioxidant and anti-inflammatory properties. Here, we evaluated Curcumin’s protective role in Aluminum Chloride (AlCl3)-induced toxicity in D. melanogaster. A 21-day survival analysis was carried out and subsequently, flies were exposed to AlCl3 (100 and 200 mg/kg diet) and/or Curcumin (0.2 and 0.5 mg/kg diet) for 7 days. Curcumin restored AlCl3-induced inhibition of glutathione S-transferase (GST) and catalase activities, as well as depletion of total thiol and glutathione contents. In addition, Curcumin ameliorated AlCl3-induced increase in acetylcholinesterase activity and accumulation of hydrogen peroxide and nitrite levels in flies. Additionally, AlCl3-induced disruption of climbing activity and emergence rate were ameliorated by curcumin in D. melanogaster (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect