A comparative in vivo study of strontium-functionalized and SLActive™ implant surfaces in early bone healing

Autor: M. Sillassen, Ole Zoffmann Andersen, K.P. Almtoft, Inge Hald Andersen, Morten Foss, Vincent Offermanns, Frank Kloss
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
wettability
Pharmaceutical Science
02 engineering and technology
OSSEOINTEGRATION
OSTEOPOROSIS
bone
Bone remodeling
Coating
Osteogenesis
International Journal of Nanomedicine
Drug Discovery
Femur
physical vapor deposition
Original Research
Titanium
bioactive
Prostheses and Implants
General Medicine
021001 nanoscience & nanotechnology
DENTAL IMPLANTS
Rabbits
PARTIALLY EDENTULOUS PATIENTS
0210 nano-technology
Materials science
Surface Properties
RANELATE
Biophysics
Bioengineering
Bone healing
engineering.material
Bone and Bones
Osseointegration
OSTEOBLAST DIFFERENTIATION
Biomaterials
03 medical and health sciences
Bone-Implant Interface
Animals
ACID-ETCHED SURFACE
biofunctionalization
Organic Chemistry
TI IMPLANTS
TITANIUM IMPLANTS
Surface coating
030104 developmental biology
Strontium
Physical vapor deposition
Microscopy
Electron
Scanning
engineering
Surface modification
Implant
surface modification
HYDROPHILICITY
Biomedical engineering
Zdroj: Offermanns, V, Andersen, O Z, Sillassen, M, Almtoft, K P, Andersen, I H, Kloss, F & Foss, M 2018, ' A comparative in vivo study of strontium-functionalized and SLActive (TM) implant surfaces in early bone healing ', International Journal of Nanomedicine, vol. 13, pp. 2189-2197 . https://doi.org/10.2147/IJN.S161061
International Journal of Nanomedicine
ISSN: 1178-2013
DOI: 10.2147/ijn.s161061
Popis: Vincent Offermanns,1 Ole Z Andersen,2 Michael Sillassen,2 Klaus P Almtoft,3 Inge H Andersen,3 Frank Kloss,4 Morten Foss2,5 1Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark; 3Tribology Center, Danish Technological Institute, Aarhus, Denmark; 4Private Practice, Lienz, Austria; 5Department of Physics and Astronomy, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark Purpose: Studies have shown that strontium-doped medical applications benefit bone metabolism leading to improved bone healing and osseointegration. Based on this knowledge, the aim of the study was to evaluate the performance of an implant surface, functionalized by a physical vapor deposition (PVD) coating (Ti-Sr-O), designed to yield predictable release of strontium. The Ti-Sr-O functionalized surface is compared to a routinely used, commercially available surface (SLActive™) with respect to bone-to-implant contact (BIC%) and new bone formation (BF%) in two defined regions of interest (ROI-I and ROI-II, respectively).Materials and methods: Ti-Sr-O functionalized, SLActive, and Grade 4 titanium implants were inserted in the femoral condyle of adult male New Zealand White rabbits. The PVD magnetron-sputtered Ti-Sr-O surface coating was characterized using scanning electron microscopy (SEM) for morphology and coating thickness. Strontium release and mechanical stability of the coating, under simulated insertion conditions, were evaluated. Furthermore, histomorphometrical BIC and BF were carried out 2 weeks after insertion.Results: Histomorphometry revealed increased bone formation of Ti-Sr-O with significant differences compared to SLActive and Grade 4 titanium in both regions of interest, ROI-I and ROI-II, at 0–250 µm and 250–500 µm distance from the implant surfaces. Analogous results of bone-to-implant contact were observed for the two modified surfaces. Conclusion: The results show that a nanopatterned Ti-Sr-O functionalized titanium surface, with sustained release of strontium, increases peri-implant bone volume and could potentially contribute to enhancement of bone anchorage of osseointegrated implants. Keywords: biofunctionalization, wettability, physical vapor deposition, bioactive, surface modification, bone 
Databáze: OpenAIRE
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