Benzo[a]pyrene impairs the migratory pattern of human gonadotropin-releasing-hormone-secreting neuroblasts
| Autor: | Paolo Comeglio, Linda Vignozzi, Matteo Becatti, Giulia Guarnieri, Annamaria Morelli, Gabriella B. Vannelli, Mario Maggi |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
animal structures Histology cell migration QH301-705.5 Biophysics EDCs Gonadotropin-releasing hormone Biology Article Gonadotropin-Releasing Hormone Fetus Neural Stem Cells Olfactory Mucosa Neuroblast Endocrine disrupting compound Cell Movement Benzo(a)pyrene polycyclic compounds medicine Humans pollution reproductive function Reproductive system Biology (General) Neurons GnRH Neuron benzo[a]pyrene hypogonadotropic hypogonadism Cell migration Cell Biology Cell biology GnRH neurons medicine.anatomical_structure Hypothalamus embryonic structures Olfactory epithelium hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Histochemistry : EJH European Journal of Histochemistry, Vol 65, Iss s1 (2021) |
| ISSN: | 2038-8306 1121-760X |
| DOI: | 10.4081/ejh.2021.3282 |
| Popis: | Benzo[a]pyrene (BaP) is a widespread pollutant that can act as an endocrine disrupting compound (EDC) and interferes with reproductive function. The central regulatory network of the reproductive system is mediated by gonadotropin-releasing hormone (GnRH) neurons, which originate in the olfactory placode and, during ontogenesis, migrate into the hypothalamus. Given the importance of the migratory process for GnRH neuron maturation, we investigated the effect of BaP (10 µM for 24 h) on GnRH neuroblasts isolated from the human fetal olfactory epithelium (FNCB4). BaP exposure significantly reduced the mRNA level of genes implicated in FNCB4 cell migration and affected their migratory ability. Our findings demonstrate that BaP may interfere with the central neuronal network controlling human reproduction affecting GnRH neuron maturation. |
| Databáze: | OpenAIRE |
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