Re-examining the HIV ‘functional cure’ oxymoron: Time for precise terminology?
| Autor: | Hursch Patel, Danielle Campbell, Kelly E. Perry, John A. Sauceda, Jeff Taylor, Brandon Brown, Laurie Sylla, Jo Gerrard, Parya Saberi, Luke Newton, Loreen Willenberg, Karine Dubé, Michael J. Peluso, John Kanazawa, Christopher Roebuck, David Palm, Lynda Dee |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epidemiology Immunology Human immunodeficiency virus (HIV) medicine.disease_cause Microbiology Terminology 03 medical and health sciences 0302 clinical medicine Viewpoint Oxymoron Virology Control medicine 030212 general & internal medicine Meaning (existential) Language Suppression Community engagement Public Health Environmental and Occupational Health Immunity HIV Functional cure QR1-502 Epistemology HIV cure research Good Health and Well Being 030104 developmental biology Infectious Diseases Expression (architecture) Journal of virus eradication HIV/AIDS Public aspects of medicine RA1-1270 Infection Psychology |
| Zdroj: | Journal of Virus Eradication, Vol 6, Iss 4, Pp 100017-(2020) Journal of Virus Eradication Journal of virus eradication, vol 6, iss 4 |
| ISSN: | 2055-6640 |
| Popis: | For over a decade, the binary concepts of 'sterilizing' versus 'functional' cure have provided an organizing framework for the field of HIV cure-related research. In this article, we examine how the expression 'functional cure' is employed within the field, published literature, and community understanding of HIV cure research. In our synthesis of the different meanings attributed to 'functional cure' within contemporary biomedical discourse, we argue that employing the 'functional cure' terminology poses a series of problems. The expression itself is contradictory and inconsistently used across a wide array of HIV cure research initiatives. Further, the meaning and acceptability of 'functional cure' within communities of people living with and affected by HIV is highly variable. After drawing lessons from other fields, such as cancer and infectious hepatitis cure research, we summarize our considerations and propose alternative language that may more aptly describe the scientific objectives in question. We call for closer attention to language used to describe HIV cure-related research, and for continued, significant, and strategic engagement to ensure acceptable and more precise terminology. |
| Databáze: | OpenAIRE |
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