Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring
Autor: | Charles R. Mackay, Samantha L. Dawson, Sarath Ranganathan, John Molloy, John B. Carlin, Michael A. Conlon, Karen E. Nelson, Laurence Macia, David Topping, Margarita Moreno-Betancur, Mimi L.K. Tang, Katrina J. Allen, Fiona Collier, Jennifer J. Koplin, Leonard C. Harrison, Richard Saffery, Martin O'Hely, Peter D. Sly, Angela Pezic, Peter Vuillermin, Anne-Louise Ponsonby, Lawrence E. K. Gray |
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Přispěvatelé: | Dwyer, T |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Epidemiology Offspring Science 030106 microbiology Prevotella Mothers General Physics and Astronomy Disease Gut flora Paediatric research Article General Biochemistry Genetics and Molecular Biology Feces 03 medical and health sciences Medical research Pregnancy Food allergy Humans Medicine Microbiome lcsh:Science 2. Zero hunger Family Characteristics Multidisciplinary biology business.industry Microbiota Infant General Chemistry biology.organism_classification medicine.disease Anti-Bacterial Agents Diet 3. Good health 030104 developmental biology Carriage Risk factors Immunology Female lcsh:Q business Food Hypersensitivity |
Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020) Nature Communications |
ISSN: | 2041-1723 |
Popis: | In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri. Incidence of food allergy in westernized populations is associated with low abundance of Prevotella. Here, the authors analyse the microbiome of a mother-infant prebirth cohort and find that maternal carriage, but not infant carriage, of P. copri during pregnancy predicts the absence of food allergy in the offspring. |
Databáze: | OpenAIRE |
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