Effects of HIFU induced cavitation on flooded lung parenchyma
| Autor: | Georg Dietrich, K.-V. Jenderka, Thomas G. Lesser, Carsten Boltze, Frank Wolfram |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Pathology medicine.medical_specialty medicine.medical_treatment lcsh:R895-920 030218 nuclear medicine & medical imaging Focal zone 03 medical and health sciences 0302 clinical medicine Parenchyma Medicine Radiology Nuclear Medicine and imaging Lung cancer Cavitation Lung business.industry Research Ultrasound fungi food and beverages HIFU respiratory system medicine.disease Ablation High-intensity focused ultrasound High intensity focused ultrasound respiratory tract diseases medicine.anatomical_structure 030220 oncology & carcinogenesis Lung flooding business |
| Zdroj: | Journal of Therapeutic Ultrasound, Vol 5, Iss 1, Pp 1-8 (2017) Journal of Therapeutic Ultrasound |
| ISSN: | 2050-5736 |
| DOI: | 10.1186/s40349-017-0099-6 |
| Popis: | High intensity focused ultrasound (HIFU) has gained clinical interest as a non-invasive local tumour therapy in many organs. In addition, it has been shown that lung cancer can be targeted by HIFU using One-Lung Flooding (OLF). OLF generates a gas free saline-lung compound in one lung wing and therefore acoustic access to central lung tumours. It can be assumed that lung parenchyma is exposed to ultrasound intensities in the pre-focal path and in cases of misguiding. If so, cavitation might be induced in the saline fraction of flooded lung and cause tissue damage. Therefore this study was aimed to determine the thresholds of HIFU induced cavitation and tissue erosion in flooded lung. Resected human lung lobes were flooded ex-vivo. HIFU (1,1 MHz) was targeted under sonographic guidance into flooded lung parenchyma. Cavitation events were counted using subharmonic passive cavitation detection (PCD). B-Mode imaging was used to detect cavitation and erosion sonographically. Tissue samples out of the focal zone were analysed histologically. In flooded lung, a PCD and a sonographic cavitation detection threshold of 625 Wcm − 2(p r = 4, 3 MPa) and 3.600 Wcm − 2(p r = 8, 3 MPa) was found. Cavitation in flooded lung appears as blurred hyperechoic focal region, which enhances echogenity with insonation time. Lung parenchyma erosion was detected at intensities above 7.200 Wcm − 2(p r = 10, 9 MPa). Cavitation occurs in flooded lung parenchyma, which can be detected passively and by B-Mode imaging. Focal intensities required for lung tumour ablation are below levels where erosive events occur. Therefore focal cavitation events can be monitored and potential risk from tissue erosion in flooded lung avoided. |
| Databáze: | OpenAIRE |
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