MicroRNA-98 is a prognostic factor for asbestos-induced mesothelioma
| Autor: | Guanghwi Kim, Yun Hak Kim, Hye Jin Heo, Hyeoncheol Oh, Youngjoo Kim, Kihun Kim, Ji Wan Kang, Junho Kang, Yeji Ko, Jungwon Kim, Eun Jung Kwon, Mihyang Ha |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Mesothelioma 0301 basic medicine Oncology Prognostic factor medicine.medical_specialty Poor prognosis Health Toxicology and Mutagenesis Down-Regulation Toxicology medicine.disease_cause Asbestos 03 medical and health sciences 0302 clinical medicine Internal medicine microRNA Biomarkers Tumor medicine Humans neoplasms Short survival Aged Pleural mesothelioma business.industry Cancer Middle Aged respiratory system medicine.disease respiratory tract diseases Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Carcinogens Female business |
| Zdroj: | Journal of Toxicology and Environmental Health, Part A. 83:126-134 |
| ISSN: | 1087-2620 1528-7394 |
| DOI: | 10.1080/15287394.2020.1734891 |
| Popis: | Malignant pleural mesothelioma (MPM) is a type of cancer characterized by a short survival time and poor prognosis. Malignant pleural mesothelioma is most frequently associated with exposure to asbestos and other elongated mineral fibers. The aim of this study was to examine molecular differences between asbestos-exposed and non-exposed MPM patients and assess prognostic significances of molecular factors. Clinical and genetic data were downloaded from Cancer Genome Atlas. To identify the molecular differences, Significant Analysis of Microarray method was used. Prognostic significances of differentially expressed genes were confirmed by using Kaplan-Meier curve with the Log-Rank test. Although mRNAs did not exhibit any significant differences between the two patient groups, nine miRNAs were found to be down-regulated in the asbestos-exposed group. The top five pathways most relevant to the selected miRNAs were extracted through pathway enrichment analysis. Survival analysis revealed that high expression of only hsa-miR-98 was significantly associated with poor prognosis in patients with asbestos-exposed MPM. Evidence suggests that management of the aggressiveness and progression of asbestos-induced MPM may require high levels of hsa-miR-98 due to its tumor-suppressive role. This study might be helpful in enhancing our understanding of the biological mechanisms underlying asbestos-induced MPM and for acquiring greater insights into targeted therapy. |
| Databáze: | OpenAIRE |
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