Quantitative Analysis of Inflammation in Orbital Fat of Thyroid-associated Ophthalmopathy Using MRI Signal Intensity

Autor: Tomoaki Higashiyama, Masahito Ohji, Maki Iwasa
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
Pathology
medicine.medical_specialty
Adolescent
genetic structures
lcsh:Medicine
030209 endocrinology & metabolism
Inflammation
Inversion recovery
Extraocular muscles
Severity of Illness Index
Article
03 medical and health sciences
Young Adult
0302 clinical medicine
Orbital fat
Medicine
Humans
lcsh:Science
Thyroid-Associated Ophthalmopathy
Multidisciplinary
medicine.diagnostic_test
business.industry
lcsh:R
Age Factors
Magnetic resonance imaging
Middle Aged
Magnetic Resonance Imaging
eye diseases
Graves Ophthalmopathy
Ophthalmology
medicine.anatomical_structure
Adipose Tissue
Oculomotor Muscles
Case-Control Studies
Pediatrics
Perinatology and Child Health
030221 ophthalmology & optometry
Female
lcsh:Q
sense organs
medicine.symptom
Signal intensity
business
Nuclear medicine
Quantitative analysis (chemistry)
Orbit
Orbit (anatomy)
Zdroj: Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
Scientific Reports
ISSN: 2045-2322
Popis: We quantitatively analyzed inflammation in orbital fat from cases of thyroid-associated ophthalmopathy (TAO) using short-tau inversion recovery (STIR) sequences from magnetic resonance imaging. The signal intensity ratios (SIRs) of orbital fat as well as the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles on STIR images were measured in 70 eyes from 70 treatment-naive TAO patients (active TAO group, 19 patients; inactive TAO group, 51 patients) and 20 eyes from 20 controls. The mean SIR in the active TAO group was significantly higher than that in the inactive TAO group and controls (P P r = 0.64), IR (r = 0.55), LR (r = 0.58), MR (r = 0.71), and SO (r = 0.65). The SIR of orbital fat had a significant positive correlation with the CAS (r = 0.53, P
Databáze: OpenAIRE
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