Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking

Autor: Hubert Hilbi, Amanda Welin, Kevin Bärlocher
Přispěvatelé: University of Zurich, Hilbi, Hubert
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Retromer
lcsh:QR1-502
Vacuole
host-pathogen interaction
sorting nexin
Endoplasmic Reticulum
Legionella pneumophila
2726 Microbiology (medical)
lcsh:Microbiology
Dictyostelium
Sorting Nexins
effector protein
biology
Chemistry
10179 Institute of Medical Microbiology
2404 Microbiology
Dictyostelium discoideum
retrograde transport
Cell biology
Protein Transport
Infectious Diseases
Host-Pathogen Interactions
symbols
retromer
Microbiology (medical)
Endosome
Mini Review
Immunology
Legionella
610 Medicine & health
Endosomes
Microbiology
Type IV Secretion Systems
03 medical and health sciences
symbols.namesake
Bacterial Proteins
Secretion
Secretory pathway
pathogen vacuole
2403 Immunology
Endoplasmic reticulum
2725 Infectious Diseases
Golgi apparatus
biology.organism_classification
Virology
type IV secretion
030104 developmental biology
Vacuoles
570 Life sciences
Zdroj: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Frontiers in Cellular and Infection Microbiology
ISSN: 2235-2988
DOI: 10.3389/fcimb.2017.00482/full
Popis: Retrograde trafficking from the endosomal system through the Golgi apparatus back to the endoplasmic reticulum is an essential pathway in eukaryotic cells, serving to maintain organelle identity and to recycle empty cargo receptors delivered by the secretory pathway. Intracellular replication of several bacterial pathogens, including Legionella pneumophila, is restricted by the retrograde trafficking pathway. L. pneumophila employs the Icm/Dot type IV secretion system (T4SS) to form the replication-permissive Legionella-containing vacuole (LCV), which is decorated with multiple components of the retrograde trafficking machinery as well as retrograde cargo receptors. The L. pneumophila effector protein RidL is secreted by the T4SS and interferes with retrograde trafficking. Here, we review recent evidence that the LCV interacts with the retrograde trafficking pathway, discuss the possible sites of action and function of RidL in the retrograde route, and put forth the hypothesis that the LCV is an acceptor compartment of retrograde transport vesicles.
Databáze: OpenAIRE
Externí odkaz: