Cord blood procalcitonin level and early-onset sepsis in extremely preterm infants

Autor: Valérie Biran, Damir Mohamed, Ludmia Taibi, Stéphane Bonacorsi, Marina Colella, Alice Frérot, Corinne Alberti, Olivier Baud
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Microbiological culture
Procalcitonin/blood
030106 microbiology
Population
Fetal Blood/chemistry
Early-onset sepsis
Neonatal Sepsis/diagnosis/microbiology
Gastroenterology
Sensitivity and Specificity
Procalcitonin
03 medical and health sciences
0302 clinical medicine
Pregnancy
Internal medicine
Medicine
Humans
030212 general & internal medicine
Neonatology
Prospective Studies
Prospective cohort study
education
Extremely preterm infants
education.field_of_study
ddc:618
Neonatal sepsis
business.industry
Mortality rate
Infant
Newborn
General Medicine
medicine.disease
Fetal Blood
Biological marker
Infectious Diseases
ROC Curve
Cord blood
Infant
Extremely Premature
Female
Neonatal Sepsis
business
hormones
hormone substitutes
and hormone antagonists
Biomarkers
Biomarkers/blood
Zdroj: European Journal of Clinical Microbiology & Infectious Diseases, Vol. 38, No 9 (2019) pp. 1651-1657
ISSN: 0934-9723
Popis: Early-onset neonatal sepsis (EOS) is observed in 1.7% of extremely preterm infants, with high morbidity and mortality rate. Cord blood procalcitonin (PCT) is a sensitive marker of EOS in full-term newborns, but it has been rarely studied in premature infants. The diagnostic value of cord blood PCT by immunofluorescence has been assessed as an early marker of EOS in a prospective cohort of extremely preterm infants, with a threshold at 0.5 μg/L. EOS was defined by a positive bacterial culture or by the association of postnatal biological/clinical signs of EOS and antibiotic treatment for more than 72 h. Correlation between PCT serum concentrations and postnatal morbidities was also analyzed. Among a total of 186 infants, 45 (24%) were classified as EOS. Blood PCT concentration was ≤ 0.5 μg/L in 114 infants, including 11 EOS (9.6%) and PCT was > 0.5 μg/L in 72 babies including 34 EOS (47.2%). PCT concentration > 0.5 μg/L was associated with higher risk of EOS (OR 2.18; CI95% 1.58-3.02; p 0.5 μg/L (OR 2.58; CI95% 1.35-4.94; p = 0.004). Cord blood PCT is a marker significantly associated with EOS in extremely preterm infants, but its sensitivity remains low. Its added value in combination with other early marker of EOS needs to be further investigated in this high-risk population.
Databáze: OpenAIRE
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