The Relative Risk of Developing Type 2 Diabetes Mellitus in Young Adults with Schizophrenia Treated with Different Atypical Antipsychotic
| Autor: | Nicolae-Marius Cason, Enikő Béres, Petru Aurel Babeș, Katalin Babeș |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Olanzapine
diabetes mellitus type 2 Pediatrics medicine.medical_specialty endocrine system diseases medicine.drug_class olanzapine Specialties of internal medicine Atypical antipsychotic 03 medical and health sciences 0302 clinical medicine second-generation antipsychotic agents medicine Cumulative incidence Young adult business.industry Incidence (epidemiology) nutritional and metabolic diseases Type 2 Diabetes Mellitus medicine.disease 030227 psychiatry schizophrenia RC581-951 Schizophrenia Relative risk young adult metabolic side effects of drugs and substances business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Romanian Journal of Diabetes Nutrition and Metabolic Diseases, Vol 26, Iss 4, Pp 445-453 (2019) |
| ISSN: | 2284-6417 |
| DOI: | 10.2478/rjdnmd-2019-0047 |
| Popis: | Background and aim: While the link between antipsychotic treatment and metabolic adverse events, including type 2 diabetes mellitus (T2DM) are clear in adults with schizophrenia, in young this association is not so well studied although the use of secondgeneration antipsychotics (SGA) is more and more frequent.Material and methods: The local diabetes register was compared with the list of all registered young adults (18-35 years) with schizophrenia 2 years retrospective and 2 years prospective. Cumulative incidence, rate of incidence and relative risk was calculated knowing the number of persons in this age group within this region.Results: Cumulative incidence for exposed group was 0.7% with a rate of incidence of 6.27 (95%CI: 4.1-10.5) per 1,000 patientyears, when in normal population was 0.2%, respectively 2.01 (95%CI: 0.72-3.79). This means a relative risk of 3.4736 (95%CI: 1.79-6.72), p=0.0002 and NNH=202 (95%CI: 134-404). Multivariate analysis showed that gender male (OR=1.83; 95%CI: 0.9-2.7; p=0.002) and olanzapine prescription (OR=4.76; 95%CI: 1.7-7.7; p=0.0001) were independent risk factors for T2DM.Conclusions: The metabolic risk should be taken in account every time introducing or changing a SGA in young schizophrenic patient, balancing the benefits and negative metabolic effects (especially with olanzapine). Healthy nutrition and physical activities are necessary components of these patients lifestyle to avoid early onset of T2DM. |
| Databáze: | OpenAIRE |
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