Porphyromonas gingivalis infection exacerbates oesophageal cancer and promotes resistance to neoadjuvant chemotherapy
| Autor: | Shegan Gao, Lanhai Lu, Xiaoxian Duan, Fuyou Zhou, Richard J. Lamont, Zhen Gu, Lan Yakoumatos, Jiong Li, Muddasir Mohammed, Xiang Yuan, Shuang Liang, Junling Ren, David A. Scott, Ke Liu, Yiwen Liu, Huizhi Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Esophageal Neoplasms Cell Survival medicine.medical_treatment Article Metastasis Pathogenesis Mice 03 medical and health sciences 0302 clinical medicine In vivo Internal medicine Bacteroidaceae Infections Animals Humans Medicine Stage (cooking) Porphyromonas gingivalis Cell Proliferation Neoplasm Staging Retrospective Studies Chemotherapy biology business.industry Cancer Prognosis medicine.disease biology.organism_classification Survival Analysis Xenograft Model Antitumor Assays Neoadjuvant Therapy digestive system diseases Treatment Outcome Chemotherapy Adjuvant Drug Resistance Neoplasm Apoptosis 030220 oncology & carcinogenesis Female Esophageal Squamous Cell Carcinoma Tomography X-Ray Computed business |
| Zdroj: | Br J Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | BACKGROUND: The effect of Porphyromonas gingivalis (Pg) infection on oesophageal squamous cell carcinoma (ESCC) prognosis, chemotherapeutic efficacy, and oesophageal cancer cell apoptosis resistance and proliferation remain poorly understood. METHODS: Clinicopathological data from 312 ESCC oesophagectomy patients, along with the computed tomography imaging results and longitudinal cancerous tissue samples from a patient subset (n = 85) who received neoadjuvant chemotherapy (NACT), were analysed. Comparison of overall survival and response rate to NACT between Pg-infected and Pg-uninfected patients was made by multivariate Cox analysis and Response Evaluation Criteria in Solid Tumours v.1.1 criteria. The influence of Pg on cell proliferation and drug-induced apoptosis was examined in ESCC patients and validated in vitro and in vivo. RESULTS: The 5-year overall survival was lower in Pg-positive patients, and infection was associated with multiple clinicopathological factors and pathologic tumour, node, metastasis stage. Of the 85 patients who received NACT, Pg infection was associated with a lower response rate and 5-year overall survival. Infection with Pg resulted in apoptosis resistance in ESCC and promoted ESCC cell viability, which was confirmed in longitudinal cancerous tissue samples. Pg-induced apoptosis resistance was dependent on fimbriae and STAT3. CONCLUSIONS: Pg infection is associated with a worse ESCC prognosis, reduced chemotherapy efficacy, and can potentiate the aggressive behaviour of ESCC cells. |
| Databáze: | OpenAIRE |
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