Structure Assignment of Seized Products Containing Cathinone Derivatives Using High Resolution Analytical Techniques
| Autor: | Vera L. Alves, João L. Gonçalves, Helena M. Teixeira, Joselin Aguiar, Maria J. Caldeira, José S. Câmara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Methylone lcsh:QR1-502 Infrared spectroscopy 01 natural sciences Biochemistry Article lcsh:Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Synthetic cathinones 030216 legal & forensic medicine Methedrone Fourier transform infrared spectroscopy Molecular Biology Métodos de Análise Chromatography chemical characterization synthetic cathinones Catinonas Sintéticas 010401 analytical chemistry Pentedrone Nuclear magnetic resonance spectroscopy NMR 0104 chemical sciences Buphedrone New psychoactive substances chemistry FTIR Novas Substâncias Psicoativas new psychoactive substances Chemical characterization Gas chromatography–mass spectrometry GC-MS medicine.drug |
| Zdroj: | Metabolites, Vol 11, Iss 144, p 144 (2021) Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP Metabolites Volume 11 Issue 3 |
| ISSN: | 2218-1989 |
| Popis: | The innovation of the new psychoactive substances (NPS) market requires the rapid identification of new substances that can be a risk to public health, in order to reduce the damage from their use. Twelve seized products suspected to contain illicit substances were analyzed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), gas chromatography coupled to mass spectrometry (GC-MS), and nuclear magnetic resonance spectroscopy (NMR). Synthetic cathinones (SCat) were found in all products, either as a single component or in mixtures. Infrared spectra of all products were consistent with the molecular structure of SCat, showing an intense absorption band at 1700-1674 cm-1, corresponding to the carbonyl stretching, a medium/strong peak at 1605-1580 cm-1, indicating stretching vibrations in the aromatic ring (C=C) and bands with relative low intensity at frequencies near 2700-2400 cm-1, corresponding to an amine salt. It was possible to identify a total of eight cathinone derivatives by GC-MS and NMR analysis: 4'-methyl-α-pyrrolidinohexanophenone (MPHP), α-pyrrolidinohexanophenone (α-PHP), 3-fluoromethcathinone (3-FMC), methedrone, methylone, buphedrone, N-ethylcathinone, and pentedrone. Among the adulterants found in these samples, caffeine was the most frequently detected substance, followed by ethylphenidate. These results highlight the prevalence of SCat in seized materials of the Portuguese market. Reference standards are usually required for confirmation, but when reference materials are not available, the combination of complementary techniques is fundamental for a rapid and an unequivocal identification of such substances. M1420-01-0145-FEDER-000005 M1420-01-0145-FEDER-000008 info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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