Overview of the role of Shiga toxins in porcine edema disease pathogenesis
| Autor: | Gabriela C. Dailoff, David Arenas, Leandro M. Redondo, Natalia A. Casanova, Mariano E. Fernandez Miyakawa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Necrosis Swine STX 2E EDEMA DISEASE PATHOGENESIS 030106 microbiology Virulence Disease Toxicology medicine.disease_cause Shiga Toxin 2 Virulence factor Microbiology Pathogenesis Feces 03 medical and health sciences STX2 Otras Ciencias Veterinarias SHIGA TOXIN medicine Animals SWINE Escherichia coli Escherichia coli Infections Swine Diseases Globosides Shiga-Toxigenic Escherichia coli biology Ciencias Veterinarias Shiga toxin 030104 developmental biology CIENCIAS AGRÍCOLAS biology.protein medicine.symptom |
| Zdroj: | Toxicon. 148:149-154 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2018.04.019 |
| Popis: | Shiga toxin-producing Escherichia coli (STEC) have been implicated as the cause of enterotoxemias, such as hemolytic uremic syndrome in humans and edema disease (ED) of pigs. Stx1 and Stx2 are the most common types found in association with illness, but only Stx2e is associated with disease in the animal host. Porcine edema disease is a serious affection which can lead to dead causing great losses of weaned piglets. Stx2e is the most frequent Stx variant found in porcine feces and is considered the key virulence factor involved in the pathogenesis of porcine edema disease. Stx2e binds with higher affinity to Gb4 receptor than to Gb3 which could be due to amino acid changes in B subunit. Moreover, this subtype also binds to Forssman glycosphingolipids conferring upon Stx2e a unique promiscuous recognition feature. Manifestations of edema disease are caused by systemic effects of Stx2e with no significant morphologic changes in enterocytes. Endothelial cell necrosis in the brain is an early event in the pathogenesis of ED caused by Stx2e-producing STEC strains. Further studies are needed to generate techniques and tools which allow to understand the circulation and ecology of STEC strains in pigs even in resistant animals for diagnostic and epidemiological purposes. Fil: Casanova, Natalia Andrea. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Redondo, Leandro Martin. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Dailoff, Gabriela Cecilia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Arenas, David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Fernandez Miyakawa, Mariano Enrique. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| Databáze: | OpenAIRE |
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