Hypothalamus-pituitary-adrenal axis involves in anti-viral ability through regulation of immune response in piglets infected by highly pathogenic porcine reproductive and respiratory syndrome virus

Autor: En-Min Zhou, Chenggang Jiang, Jianan Wu, Gang Wang, Shujie Wang, Ying Yu, Yabin Tu, Hai Li, Jie Tong, Linlin Zheng, Yonggang Liu, Xuehui Cai, Chong Zhang
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Hypothalamo-Hypophyseal System
endocrine system
Swine
animal diseases
Porcine Reproductive and Respiratory Syndrome
Pituitary-Adrenal System
Real-Time Polymerase Chain Reaction
Proinflammatory cytokine
03 medical and health sciences
Immune system
Animals
Medicine
Porcine respiratory and reproductive syndrome virus
Pathological
Dexamethasone
Proinflammatory cytokines
lcsh:Veterinary medicine
General Veterinary
biology
business.industry
HP-PRRSV
virus diseases
Outbreak
General Medicine
Mifepristone
Viral Load
respiratory system
Porcine reproductive and respiratory syndrome virus
biology.organism_classification
Hypothalamus-pituitary-adrenal axis
030104 developmental biology
Animals
Newborn
Hypothalamus
Immunology
Cytokines
lcsh:SF600-1100
Female
business
hormones
hormone substitutes
and hormone antagonists
Research Article
medicine.drug
Zdroj: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-7 (2018)
BMC Veterinary Research
ISSN: 1746-6148
Popis: Background The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has been responsible for several viral attacks in the Asian porcine industry, since the first outbreak in China in 2006. During the early stages of the HP-PRRSV infection, high levels of proinflammatory cytokines are noted in the host peripheral blood, which are accompanied by severe lesions in the lungs and immune system organs; these are considered as the greatest contributors to the overall disease burden. We hypothesized that the anti-PRRSV response in piglets might be mediated by the hypothalamus-pituitary-adrenal (HPA) axis, which led to a decrease in the psycho-neuroendocrinological manifestation of HP-PRRSV etiology via immune response regulation. Results We investigated the regulation of the HPA axis in HP-PRRSV-infected piglets that were treated with 1 mg/kg body weight (b. w.)/day mifepristone (RU486) or 2 mg/kg b.w./day dexamethasone (DEX). Both RU486 and DEX enhanced the disease status of the piglets infected by the HP-PRRSV HuN4 strain, resulting in high mortality and more severe pathological changes in the lungs. Conclusions HP-PRRSV infection activates the HPA axis, and artificial regulation of the immune-endocrine system enhances disease severity in HP-PRRSV-infected piglets. Thus, DEX and RU486 should be avoided in the clinical treatment of HP-PRRS. Electronic supplementary material The online version of this article (10.1186/s12917-018-1414-3) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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