Detection of response to tumor microenvironment–targeted cellular immunotherapy using nano-radiomics
| Autor: | Ananth Annapragada, Robin Parihar, Ketan B. Ghaghada, Zbigniew Starosolski, Laxman Devkota, Charlotte H. Rivas, Igor Stupin |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Immunology Cell Tumor response law.invention 03 medical and health sciences 0302 clinical medicine Radiomics law Neoplasms Tumor Microenvironment medicine Animals Humans Solid tumor Research Articles Cancer 030304 developmental biology 0303 health sciences Tumor microenvironment Multidisciplinary business.industry Myeloid-Derived Suppressor Cells SciAdv r-articles Immunotherapy Killer Cells Natural medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Suppressor sense organs Cellular immunotherapy business Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Data mining of nanoparticle contrast–enhanced 3D images reveals phenotypes indicative of tumor response to cellular immunotherapy. Immunotherapies, including cell-based therapies, targeting the tumor microenvironment (TME) result in variable and delayed responses. Thus, it has been difficult to gauge the efficacy of TME-directed therapies early after administration. We investigated a nano-radiomics approach (quantitative analysis of nanoparticle contrast–enhanced three-dimensional images) for detection of tumor response to cellular immunotherapy directed against myeloid-derived suppressor cells (MDSCs), a key component of TME. Animals bearing human MDSC-containing solid tumor xenografts received treatment with MDSC-targeting human natural killer (NK) cells and underwent nanoparticle contrast–enhanced computed tomography (CT) imaging. Whereas conventional CT-derived tumor metrics were unable to differentiate NK cell immunotherapy tumors from untreated tumors, nano-radiomics revealed texture-based features capable of differentiating treatment groups. Our study shows that TME-directed cellular immunotherapy causes subtle changes not effectively gauged by conventional imaging metrics but revealed by nano-radiomics. Our work provides a method for noninvasive assessment of TME-directed immunotherapy potentially applicable to numerous solid tumors. |
| Databáze: | OpenAIRE |
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