Glycine protects preimplantation mouse conceptuses from a detrimental effect on development of the inorganic ions in oviductal fluid
| Autor: | Lon J. Van Winkle, Allan L. Campione, N. Haghighat |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Glycine
Embryonic Development Oviducts Biology Inorganic ions Embryonic and Fetal Development Mice Pregnancy medicine Animals Blastocyst Amino Acids Ions chemistry.chemical_classification Mice Inbred ICR Chi-Square Distribution Embryo General Medicine Water-Electrolyte Balance Body Fluids Amino acid Enzyme medicine.anatomical_structure Biochemistry chemistry embryonic structures Oviduct Female Animal Science and Zoology Intracellular |
| Zdroj: | Journal of Experimental Zoology. 253:215-219 |
| ISSN: | 1097-010X 0022-104X |
| DOI: | 10.1002/jez.1402530211 |
| Popis: | Two-cell mouse conceptuses were cultured in media that contained various concentrations of inorganic ions and amino acids. Substrates of the amino acid transport system Gly were detrimental to development at slightly hyposmotic concentrations of other ions. In contrast, these amino acids increased the frequency at which two-cell conceptuses developed into blastocysts at total ion concentrations of 355 to 405 mM. Data reported elsewhere is consistent with the possibility that the total ion concentration in oviductal fluid exceeds 360 mM, whereas the concentration of glycine in this fluid may be on the order of 10 mM. Therefore, a high ion concentration and glycine may counteract the potentially harmful effects of each other in situ. Like some marine organisms, preimplantation mouse conceptuses may use glycine as an intracellular osmolite because accumulation of inorganic ions could perturb the activities of some enzymes. |
| Databáze: | OpenAIRE |
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