Coronary artery diameter increase induced by a phosphodiesterase 5 inhibitor, E4021, in conscious pigs

Autor:	Hideyuki Adachi, Mayu Nishino
Rok vydání:	1998
Předmět:	medicine.medical_specialty medicine.drug_mechanism_of_action Phosphodiesterase Inhibitors Swine Pulmonary arterial pressure Piperidines 3' 5'-Cyclic-GMP Phosphodiesterases Internal medicine Heart rate medicine Animals Pharmacology Cyclic Nucleotide Phosphodiesterases Type 5 Dose-Response Relationship Drug business.industry Phosphoric Diester Hydrolases Mean Aortic Pressure Hemodynamics Intravenous Infusions Arteries Coronary Vessels Dose–response relationship medicine.anatomical_structure cGMP-specific phosphodiesterase type 5 Cardiology Quinazolines business Phosphodiesterase 5 inhibitor Artery
Zdroj:	Japanese journal of pharmacology. 77(1)
ISSN:	0021-5198
Popis:	The effects of intravenous infusions of 1, 3 and 10 microg/kg/min of the phosphodiesterase 5 inhibitor, E4021, at 30-min intervals on coronary artery diameter were studied in 8 conscious pigs monitored with a pair of piezoelectric crystals. The highest dose increased the diameter by 2.9 +/-0.5% (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e1d05f8a34a1ec5d3930c056d4f867 https://pubmed.ncbi.nlm.nih.gov/9639065 Zobrazit plný text záznamu