Effects of CPAP on right ventricular myocardial performance index in obstructive sleep apnea patients without hypertension

Autor: Sukru Gur, Fatma Evyapan, Dursun Dursunoglu, Güllü Özalp, Nese Dursunoglu, Sibel Özkurt
Rok vydání: 2006
Předmět:
Male
Time Factors
blood pressure measurement
medicine.medical_treatment
Blood Pressure
Body Mass Index
polysomnography
heart contraction
middle aged
echocardiography
Continuous positive airway pressure
Myocardial Performance Index
sleep apnea syndrome
pathophysiology
time
statistical significance
clinical article
Sleep Apnea
Obstructive
Continuous Positive Airway Pressure
adult
article
Middle Aged
Sleep in non-human animals
Right ventricular dysfunction
female
Echocardiography
positive end expiratory pressure
Anesthesia
diabetes mellitus
Hypertension
Cardiology
disease severity
Female
heart index
Pulmonary and Respiratory Medicine
Adult
medicine.medical_specialty
Polysomnography
M mode echocardiography
patient compliance
statistical analysis
Internal medicine
heart performance
medicine
Humans
controlled study
human
lcsh:RC705-779
heart ventricle enddiastolic pressure
business.industry
Research
disease association
scoring system
lcsh:Diseases of the respiratory system
heart ventricle wall
medicine.disease
Pulmonary hypertension
body mass
respiratory tract diseases
Obstructive sleep apnea
heart right ventricle function
heart right ventricle hypertrophy
Doppler echography
Ventricular Function
Right
business
heart muscle relaxation
rating scale
Zdroj: Respiratory Research
Respiratory Research, Vol 7, Iss 1, p 22 (2006)
ISSN: 1465-993X
DOI: 10.1186/1465-9921-7-22
Popis: Objectives Obstructive sleep apnoea (OSA) might cause right ventricular dysfunction and pulmonary hypertension. We aimed to determine the effects of nasal continuous positive airway pressure (CPAP) therapy on right ventricular myocardial performance index (MPI) in OSA patients without hypertension. Methods 49 subjects without hypertension, diabetes mellitus, any cardiac and pulmonary disease had overnight polysomnography and echocardiography. In 18 moderate-severe OSA (apnea-hypopnea index ≥ 15) patients, right ventricular free wall diameter (RVFWD) was measured by M-mode, and right ventricular MPI was calculated as (isovolumic contraction time+ isovolumic relaxation time) / pulmonary ejection time using Doppler at baseline and after 6 months CPAP therapy. Results Mean age was 46.5 ± 4.9 year. Patients had high body mass index (BMI: 30.6 ± 4,0 kg/m2), but there was no change in either BMI or blood pressures after 6 months. Right ventricular end-diastolic and end-systolic diameters were in normal limits at baseline, and did not change after CPAP usage. Baseline RVFWD (7.1 ± 2.1 mm) significantly decreased after CPAP therapy (6.2 ± 1.7 mm, p < 0.001). 15 of patients (83%) had right ventricular diastolic dysfunction at baseline, and it was completely improved in 11 of them (73%) by CPAP usage. Right ventricular global dysfunction was shown in 11 patients (61%) with a high MPI (62.2 ± 9.3%) at baseline; and MPI was significantly decreased after CPAP therapy (47.3 ± 8.4%, p < 0.0001), and it was completely corrected in 4 of them (36%). Conclusion CPAP therapy significantly decreases RVFWD and improves right ventricular diastolic and global functions (MPI) in OSA patients without hypertension.
Databáze: OpenAIRE
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